ADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus-pituitary-thyroid axis in male mice.

However, after treated with testosterone for a month, Adgra1 −/− female mice displayed an increasing trend in metabolic rate albeit no significant differences ( p < 0.07) when compared with controls (Supplementary Fig. 12a–i ).

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