In most MSC transplanted patients, the inflammatory factors such as IL-6, TGF-β1/2, TNF-α, and IL-1β all exhibited a decreasing trend compared to before transplantation, that was consistent with that in animal experiments ( Bao et al., 2013 ).
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Mesenchymal Stem Cells Transplantation in Intracerebral Hemorrhage: Application and Challenges.
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The incidence rate of ICH has not decreased with the development of medical and healthcare level, but shows an increasing trend in low- and middle-income countries ( Wu and Anderson, 2020 ).