Transcriptome Landscape of Epithelial to Mesenchymal Transition of Human Stem Cell-Derived RPE.

Invest Ophthalmol Vis Sci · 2021 · PMC8024778 · PMID 33792620

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An analysis of the transcripts of the genes further downstream of known canonical EMT signaling pathways also identified a number of highly significant increased expressions, including the NOTCH signaling-related genes HES1 (12-fold), HEY1 (10-fold), and JAG1 (4-fold), as well as members of other signaling pathways, such as TGFB1 (6-fold), NFKB1 (3-fold), HMGA2 (16-fold), and CTNNB1 (7-fold) ( Figs. 1 J, K).

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