Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.

Cell Stem Cell · 2021 · PMC8024900 · PMID 33301706

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highly significantno p-value reported

In overt fibrosis, MSCs showed highly significant downregulation of hematopoiesis support, MSC characteristics, and strong upregulation of ECM proteins (in all MSC clusters) and collagen (in MSC-1 and -2).

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