Regnase-1 is essential for B cell homeostasis to prevent immunopathology.

Pathway enrichment analysis showed highly significant impacts to pathways and cellular processes such as cell cycle regulation, dysregulation of GC response and other autoimmune-associated pathways, inflammatory signaling involving IL-1, IL-2, macrophage migration inhibitory factor, and survival signatures associated with B cell receptor (BCR) signaling, TNF, Bcl2, and NF-κB pathway ( Fig. 3 A and Table S1 ).

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