Association of TGFB -509C>T promoter polymorphism with primary angle closure glaucoma in a North Indian Punjabi cohort.

For POAG, only marginal significance was observed under co-dominant model ( p = 0.045, OR = 1.35; 95% CI = 1.00–1.82), which did not survive corrections.

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Genetic model analysis revealed a borderline significant association ( p = 0.045 ) of this variant under dominant model, however the results were not significant after applying corrections for confounders like age, sex and family history (p corr = 0.181). -509C > T TGFB polymorphism revealed significant association with PACG The allele and genotype frequency distribution along with genetic model analysis for PACG cases and controls are given in Table 2 .

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The difference in frequency of CC, CT and TT genotypes was marginally significant among male PACG cases (37.25, 37.25 and 25.50%) as compared to control males (26.03, 52.97 and 21.00%) ( p = 0.050, OR CT = 0.49; 95% CI = 0.24–1.00) but not among POAG males (27.23%; 58.41 and 14.36%) ( p = 0.818, OR CT = 1.05; 95% CI = 0.67–1.65).

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-509C > T TGFB polymorphism revealed a borderline significance with POAG The observed genotype count for -509C > T variant followed Hardy Weinberg equilibrium (HWE) in controls ( p = 0.144).

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