Tumour angiogenesis normalized by myo-inositol trispyrophosphate alleviates hypoxia in the microenvironment and promotes antitumor immune response.

This is highly significant for chemokines, as CCL17, which promotes cancer, is dependent on hypoxia. 55 The major changes appear in the induction of mRNAs for chemokines CXCL12 and CCL21b, confirming the role of hypoxia in the metastatic process of melanoma cells. 4 DISCUSSION The present knowledge of tumours and modern tumour‐treatment strategies is leading researchers to design new and combined approaches.

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