It has been shown that BE harbors clonality features that resemble the ones we see in a EAC even if the morphology is not yet significant; this evidence supports the theory that BE corresponds to esophageal “field cancerization”, first described by Slaughter et al. in 1953 for oral cancer [ 6 , 7 , 8 ].
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miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma.
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