Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A.

Furthermore, unlike targeting either KDM4A or KDM4B alone, dual targeting led to a highly significant increase in Caspase activity indicative of apoptosis in these cells ( Figure 6 B and Figure S10 ), suggesting that these two demethylase family members have distinct roles in RMS cell growth and that combined inhibition of both KDM4A and KDM4B is required in RMS to induce apoptosis and reduce the potential for resistance to KDM4 subfamily targeted therapies. 4.

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