Vascular endothelial growth factor B inhibits insulin secretion in MIN6 cells and reduces Ca²⁺ and cyclic adenosine monophosphate levels through PI3K/AKT pathway.

After VEGF-B expression in MIN6 cells was knocked down by siRNA, cell proliferation showed an increasing trend (Figure 1B ).

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The results showed that as the concentration of VEGF-B protein increased, insulin secretion showed a decreasing trend.

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