MicroRNA-223 restricts liver fibrosis by inhibiting the TAZ-IHH-GLI2 and PDGF signaling pathways via the crosstalk of multiple liver cell types.

Increased liver inflammation was further confirmed by the upregulation of Ccl3 and Ccl4 in miR-223KO mice, whereas Ccl2 and Il6 levels had an increasing trend although no statistical significance was reached between WT and miR-223KO mice (Fig. 1 C and Supplementary Fig.

also in 63,971 other papers