Contribution of Population Pharmacokinetics of Glycopeptides and Antifungals to Dosage Adaptation in Paediatric Onco-hematological Malignancies: A Review.

Front Pharmacol · 2021 · PMC8048069 · PMID 33867986

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may not be significantno p-value reported

As illustrated with this example, the role of pharmacogenetic biomarkers in variability may not be significant when the number of patients of deficient metabolizer genotypes is low, when PK overlap exists between the different genotypes and/or when genotype expression did not reach maturation ( Lestner et al., 2016 ).

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