CD8⁺ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity.

Independent analysis of the common CDR3 motifs was also conducted with TCRdist ( Dash et al., 2017 ) to generate highly significant alpha and beta amino acid motifs for A2/S 269 and B7/N 105 TCRs ( Figure 7 B; Figure S5 ).

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