Arginine methylation of R81 in Smad6 confines BMP-induced Smad1 signaling.

R81 methylation may be significant in the context of craniofacial development and cranial suture closure because compromised Smad6 function has been associated with the occurrence of craniosynostosis ( 35 , 36 , 37 ), a congenital condition characterized by premature fusion of bones that form the cranial vault.

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