Crystal structure of ADAMTS13 CUB domains reveals their role in global latency.

Sci Adv · 2021 · PMC8051872 · PMID 33863735

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highly significantno p-value reported

Five variants—W1245A/W1250A, K1252Q, R1326Q, E1387Q, and E1389Q—exhibited a highly significant reduction in activation ( Fig. 4, M to Q ), suggesting that the substituted residues could be of particular importance in mediating the Spacer-CUB1-2 interaction.

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