Our initial studies with a J5-affinity-purified IgG that lacked any anti- Pseudomonas LPS IgG showed highly significant protection against lethal infection caused by this same challenge strain of PA. 35 The ability of passively administered J5-specific IgG Ab to protect against PA infection strongly suggests that the protection was both Ab mediated and J5 Ag specific.
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A pilot study of an anti-endotoxin Ig-enriched bovine colostrum to prevent experimental sepsis.
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