Two additional sites, N386 in V4 and S440, both associated with resistance to V3-specific bnAbs [ 31 ], were also found to be associated with maternal transmission status, although at a more marginal significance level (FDR = 0.08 and 0.07 respectively, S3 Table ).
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Mutations that confer resistance to broadly-neutralizing antibodies define HIV-1 variants of transmitting mothers from that of non-transmitting mothers.
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