Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion.

This paper will be of highly significant impact since it shows conserved sperm molecular functions with clear genetic validation between invertebrates (fly and worm) and mammals separated by about 700 million to one billion years of evolution from a common ancestor. 10.7554/eLife.66313.sa2 Author response Essential revisions: Please complete the following revisions to make your manuscript acceptable for publication in eLife: Figure 1 of the paper shows protein alignments of DC-STAMP proteins DCST1 and DCST2 with humans, mouse, worms (SPE-42 and SPE-49) and the fly (Snky) (Figure 1A).

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