highly significantP < 10 −100
3c , upper panel; n = 3365; median CO = 0.68, IQR = 0.46–0.82), and the difference in median CO between positively responsive cells and the entire population of segmented cells ( n = 24,540; median CO = 0.44, IQR = 0.23–0.70) was highly significant ( P < 10 −100 , Wilcoxon rank-sum test).