C5aR inhibition of nonimmune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia.

J Allergy Clin Immunol · 2021 · PMC8056780 · PMID 33852936

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highly significantno p-value reported

Compared with SARS-CoV-2–infected cultures, we found a highly significant reduction in C3a desArg in both C3aR- and C5aR antagonist–treated and SARS-CoV–2 infected cells ( Fig 4 , D ; C3aR Inh/SARS-CoV-2 and C5aR Inh/SARS-CoV-2).

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