Controlling for cellular heterogeneity using single-cell deconvolution of gene expression reveals novel markers of colorectal tumors exhibiting microsatellite instability.

While we were unable to replicate differences in these genes in colon cancer cell lines, their identification in TCGA-COAD following the adjustment for cell composition does reflect the importance of performing deconvolution methods. Beyond differential expression of DNA repair genes, highly significant reductions in the expression of AGMO , LINC02577 and KIF1A in MSI-H tumors may be worth further consideration.

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