High <i>in vitro</i> and <i>in vivo</i> synergistic activity between mTORC1 and PLK1 inhibition in adenocarcinoma NSCLC.

In this model, we have confirmed that volasertib induced a slight increase of HIF1 gene expression and a dramatic drop of CA9 gene expression under therapies ( Figure 6D ); particularly, we have also observed a highly significant decrease of both VEGFA and GLUT-1 mRNA expression in the combination group in comparison to the volasertib group ( Figure 6D ).

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