lncRNA HAND2-AS1 overexpression inhibits cancer cell proliferation in hepatocellular carcinoma by downregulating RUNX2 expression.

1 , 2 The incidence of liver cancer in the United States has been stable over the past several years; however, the mortality rate of patients with liver cancer has shown an increasing trend, 3 mostly because of the increased prevalence of cancer metastasis at the time of diagnosis, which lacks radical treatment methods. 4 Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections have been proven to be major causes of liver cancer 5 ; however, the molecular mechanism underlying the pathogenesis of liver cancer remains unclear.

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