Reducing the effects of control materials based on interchangeability of estimates of day-to-day imprecision between commercial control materials and serum samples.

At the same time, the results also showed that the uncontrolled specimens are more imprecise than strictly controlled specimens, and the measured data showed a decreasing trend, which was mainly affected by the so‐called “cold denaturation.” This result was consistent with the literature reports. 5 , 6 , 7 , 8 , 12 In order to confirm whether the operation can be extended to other assays, we incorporated the operation in the conclusion into the laboratory standard operating procedure and applied it to 21 routine assays.

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