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Patterns of metformin monotherapy discontinuation and reinitiation in people with type 2 diabetes mellitus in New Zealand.

PLoS One · 2021 · PMC8059805 · PMID 33882106

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an increasing trendno p-value reported
Another study using slightly more recent dispensing data indicated an increasing trend towards people with T2DM initiating therapy with metformin in accordance with these guidelines [ 9 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.