Targeting resistance to radiation-immunotherapy in cold HNSCCs by modulating the Treg-dendritic cell axis.

A significant benefit in disease-free survival was observed with a trend towards significance for overall survival benefit in the Treg low group ( figure 1A, B ).

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While neither RT alone nor RT+ anti-CD25 increased T cell infiltration, the addition of anti-CD137 resulted in a significant increase of CD8 T cells in the tumor and an increasing trend for CD4 T cells ( figure 4K ).

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