Circadian clock dysfunction in human omental fat links obesity to metabolic inflammation.

Nat Commun · 2021 · PMC8062496 · PMID 33888702

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extremely significantno p-value reported

In all samples obtained from non-obese and obese patients, we found an extremely significant overrepresentation of the canonical E-box motif (CACGTG), a DNA response element bound by CLOCK/BMAL1 38 , 39 , in 76–81% of the targets (Fig. 5B ).

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