Low Serum Uric Acid Predicts Risk of a Composite Disease Endpoint.

Conclusions Longitudinal analysis of middle-aged hospital attendees without or with type-2 diabetes for overall mortality and a composite endpoint of death, non-fatal cardiac, or non-cardiac disease risk documented in combined gender that “reduced” SUA assays contributed significantly to non-fatal outcomes (RR around 1.5), and at borderline significance to the composite endpoint, additively to conventional cardiovascular risk factors.

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Diabetic women displayed the disparity of a borderline significant positive association of SUA with non-fatal events and the composite endpoint, likely reflecting associated pro-inflammatory state and HDL dysfunction in diabetic status.

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In highly significant models among the non-diabetic sample, the first threestated variables were significantly and positively associated, in addition to triglycerides.

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