Did the introduction and increased prescribing of antidepressants lead to changes in long-term trends of suicide rates?

In one of the most rigorously conducted ecological studies, Dahlberg and Lundin 16 showed a negative and statistically highly significant correlation between antidepressant prescriptions and the suicide rate between 1990 and 2000 in Sweden when other variables where not controlled for.

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The APC, based on the slope of the line segment, describes an increasing trend (positive APC value) or decreasing trend (negative APC value).

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The nearest joinpoints following the introduction and widespread prescription of SSRIs that mark the beginning of a decreasing trend in suicide rates were 1994 in Swiss males and 1997 in Italian males (fluoxetine, the SSRI marking a new treatment era, was introduced 1991 in Switzerland and 1989 in Italy).

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