Low-Dose Antithymocyte Globulin Has No Disadvantages to Standard Higher Dose in Pediatric Kidney Transplant Recipients: Report From the Pediatric Nephrology Research Consortium.

3 , 4 However, the lack of specific dosing recommendations until very recently has led to many immunosuppressive protocols in the adult transplant literature, with an overall trend toward a lower cumulative exposure in the most recent era. 7 , 11 , 12 , 13 We have previously demonstrated a down trend in median cumulative rATG induction dose from 7.9 mg/kg (1998–2008) to 6.3 mg/kg (2009–2016) in the North American Pediatric Renal Trials and Collaborative Studies registry. 14 In that analysis, we did not identify a difference in patient and graft outcomes using a threshold of 5 rATG induction doses (7.5 mg/kg).

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