Role of MicroRNA-145 in DNA Damage Signalling and Senescence in Vascular Smooth Muscle Cells of Type 2 Diabetic Patients.

Inhibition of ATR suggested a possible trend to increased p21 mRNA expression ( Figure 3 H). 3.4. siRNA Knockdown of DDR Kinases To confirm these pharmacological data, we employed a gene-silencing approach to individually knock down ATM, ATR and DNA-PK. siRNA inhibition caused selective and specific reduction of each target mRNA within 24 h and was maintained for at least 96 h ( Supplementary Figure S3 ).

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