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Experimental and natural evidence of SARS-CoV-2-infection-induced activation of type I interferon responses.

iScience · 2021 · PMC8074517 · PMID 33937724

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an increasing trendno p-value reported
We also identified an increasing trend for type I IFN expression (IFN-α2) in sera from moderate cases of COVID-19, relative to healthy individuals and severe cases of COVID-19.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.