Attenuation of the upregulation of NF‑κB and AP‑1 DNA‑binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression.

In the TM + rAd-SERCA2a group, the nuclear translocation of NF-κB was significantly increased by 1.40-fold (P<0.05), the transcription level of TNF-α increased by 87.4% (P<0.05) and LDH leakage exhibited an increasing trend (P>0.05) compared with the TM + rAd-EGFP group, which suggested that the overexpression of SERCA2a induced EOR ( Fig. 8 ).

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