Alendronate Alleviated Femoral Head Necrosis and Upregulated BMP2/EIF2AK3/EIF2A/ATF4 Pathway in Liquid Nitrogen Treated Rats.

Discussion Recently, reports have demonstrated that the morbidity rate of ONFH shows an increasing trend year by year and it usually affects persons from 30 to 50 years old which is urgent to find an effective option to improve bone repair and inhibit articulus collapse. 5 , 16 In particular, there are no effective treatment means except for hip replacement surgery in the late stage of ONFH and many patients require repeat surgery.

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