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Current status of opioid epidemic in the United Kingdom and strategies for treatment optimisation in chronic pain.

Int J Clin Pharm · 2021 · PMC8079300 · PMID 33252724

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an increasing trendno p-value reported
There is also an increasing trend in deaths associated with more potent opioids such as fentanyl products.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.