Association of adverse prenatal exposure burden with child psychopathology in the Adolescent Brain Cognitive Development (ABCD) Study.

There continue to be highly significant effects of adverse prenatal exposure load on CBCL scores, measured either as a dimensional or dichotomous outcome, in the initial (non-sibling) group; these effect replicate in the validation (sibling) group; and siblings who are discordant for exposure load continue to demonstrate differences in CBCL scores, where the sibling with the larger number of exposures exhibited significantly higher CBCL total score.

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