Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays.

Colchicine was tested in Phase 2a by both labs in the 48-h protocol and highly significant increases in the % MN-BN were observed in two separate experiments each at multiple doses below the cytotoxicity threshold in Lab A ( Supplementary Figure S5A and B ) and Lab C ( Supplementary Figure S5C and D ).

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