Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity.

We found that this set of mutations resulted in large, positive, and highly significant Spearman correlation coefficients in both rounds 4 (ρ = 0.83 and p -value of 8 × 10 −8 ) and 5 (ρ = 0.85 and p -value of 2 × 10 −9 ).

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