NMD inhibition by 5-azacytidine augments presentation of immunogenic frameshift-derived neoepitopes.

iScience · 2021 · PMC8082087 · PMID 33981976

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highly significantno p-value reported

The analysis of isolated splenic CD8 + T cells following immunizations with either CKAP2 - or TUBGCP3 -derived InDel neoepitopes or the positive control HPV16 peptide E7 (aa 11–19) resulted in IFNγ-specific and highly significant responses in the ELISpot assay ( Figures 5 B and 5C).

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