The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement.

212 plosbiol PLoS Biology PLoS Biol PLOS PMC8084332 8084332 8084332 33872298 10.1371/journal.pbio.3001162 The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement Vinkers Christiaan H Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision 1 * Lamberink Herm J Conceptualization, Methodology, Software, Writing – review & editing 2 Tijdink Jo

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