Barely Significant
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Conformational flexibility and structural variability of SARS-CoV2 S protein.

Structure · 2021 · PMC8086150 · PMID 33932324

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highly significantno p-value reported
More precisely, conformational modification was highly significant in two hACE2-binding loop regions (L441, K444, V445, Y449, P499, T500, and Y505) to accommodate hACE2 ( Figure 6 ).

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