highly significantp>0.10
Sensitivity analyses Calculating PDC for the LDC cohort based on the mean PDC of both substances decreased the effect size of the ATT compared to the original definition, but the results point into the same direction in all years and remained highly significant in years 2 and three (0.02, p>0.10; 0.08, p = 0.006; 0.12, p<0.001).