These finding are highly significant, as the correlation of fibroblast dysfunction with severity of manifestation, both between differently presenting animals, and between tissues within the same animal, likely demonstrates one of the main pathomechanisms mediating the observed connective tissue abnormalities.
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The Role of Cell Adhesion and Cytoskeleton Dynamics in the Pathogenesis of the Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders.
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