The role of sex and gender in the selection of Alzheimer patients for clinical trial pre-screening.

Gender-based differences in screening eligibility were only significant in patients born from 1935 to 1944 (OR = 1.23, p = 0.03) and close to significance in those born from 1925 to 1934 (OR = 1.24, p = 0.05).

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Because the incidence of AD is strongly associated with age, it is expected that population aging as well as the current lack of effective disease-modifying strategies will contribute to an increasing trend in its prevalence that will pose huge challenges to public healthcare systems across the world [ 9 ].

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