While transient hypoglycemia (study 2) caused 124% increase (124.0%±42.0%) of APP, less-severe prolonged hypoglycemia (study 1) resulted in ~26% decrease (−26.1%±21.2%) of APP in controls ( figure 4A ); this differential trend between the two studies was close to significance (p=0.07).
6–8 Elevation in key circulating AD-related proteins, such as plasma amyloid precursor protein (APP), have been reported in association with AD, with levels of APP showing a positive trend with increasing cognitive impairment. 9 10 Optimal management of T2D involving tighter glucose control increases the risk for, and frequency of, hypoglycemic episodes.