Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement.

[17] reported a decreasing trend in OTUs associated to F. prausnitzii over time when first assessing the Mars500 astronaut microbiomes, but were limited in capability to statistically compare OTUs across astronauts owing to tailoring normalisation to each astronaut as well as because low taxonomic resolution would conflate the distinct patterns of relative abundance in these F. prausnitzii ESVs.

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