Prolonged Low-Dose Dioxin Exposure Impairs Metabolic Adaptability to High-Fat Diet Feeding in Female but Not Male Mice.

In contrast, TCDDHFD islets showed a nonsignificant trend toward having only ~2-fold higher Cyp1a1 compared to COChow islets, and Cyp1a1 levels remained significantly lower than in TCDDChow islets ( Fig. 6B ).

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