LDLR inhibition promotes hepatocellular carcinoma proliferation and metastasis by elevating intracellular cholesterol synthesis through the MEK/ERK signaling pathway.

Analysis of a dataset (the Chen liver cohort) from the Oncomine database revealed a decreasing trend in LDLR expression from the normal liver tissue to the primary liver cancer site to sites of distant liver metastasis ( Figure 1 B) in the samples grouped by cancer sites.

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