Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction.

Enucleation severs RGC axons in the optic nerve, and explants maintained in culture ex vivo , demonstrated a progressive RGC loss and nuclear shrinkage observed within 12 h, with highly significant, reproducible RGC loss at 3 days ex vivo ( Fig. 2 A and B, Supplementary Fig. 1 A and B ).

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