CD8 lymphocyte depletion enhances the latency reversal activity of the SMAC mimetic AZD5582 in ART-suppressed SIV-infected rhesus macaques.

Assessment of the absolute counts of central memory (CM) and effector memory (EM) CD8 + T cells during AZD5582 treatment showed fluctuations in both the viremic and aviremic groups, with a slight trend in both groups for the EM population to expand ( Fig. 6C ).

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